Bioinformatics by D.R. Westhead, J.H. Parish & R.M. Twyman

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Bioinformatics

by D.R. Westhead, J.H. Parish & R.M. Twyman

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Instant notes in Bioinformatics is a concise yet comprehensive book for undergraduates, postgraduates and researchers who need to learn about this dynamic field. All the important areas in bioinformatics are covered in a format that is ideal for learning and rapid revision. Contents: Section A � Overview of bioinformatics � The scope of bioinformatics � Bioinformatics and the internet � Useful bioinformatics sites on the www � Section B � Data acquisition � Sequencing DNA, RNA and proteins � Determination of protein structure � Gene and protein expression data � Protein interaction data � Section C � Databases � contents, structure and annotation � File formats � Annotated sequence databases � Genome and organism-specific databases � Miscellaneous databases � Section D � Retrieval of biological data � Data retrieval with Entrez and DBGET/LinkDB � Data retrieval with SRS (sequence retrieval system) � Section E � Searching sequence databases by sequence similarity criteria � Sequence similarity searches � Amino acid substitution matrices � Database searches: FASTA and BLASTA Sequence filters � iterative database searches and PSI-BLAST � Section F � Multiple sequence alignment: gene and protein families � Multiple sequence alignment and family relationships � Protein families and pattern databases � Protein domain families � Section G � Phylogenetics � Phylogenetics, cladistics and ontology � Building phylogenetic trees � Evolution of macromolecular sequences � Section H � Sequence annotation � Principles of genome annotation � Annotation tools and resources � Section I � Structural bioinformatics � Conceptual models of protein structure � The relationship of protein three-dimensional structure to protein function � The evolution of protein structure and function � Obtaining, viewing and analyzing structural data structural alignment � Classification of proteins of known three-dimensional structure: CATH and SCOP � Introduction to protein structure prediction � Structure prediction by comparative modeling � Secondary structure prediction and prediction strategies � Section J � Microarray data analysis � Microarray data: analysis methods � Microarray data: tools and resources � Sequence sampling and SAGE � Section K � Proteomic data analysis � Analyzing data from 2D-PAGE gels � Analyzing protein mass spectrometry data � Section L � Higher-order systems � Modeling and reconstructing molecular pathways � Protein interaction informatics � Higher-order models � Section M - Cheminformatics in biology � Conventions for representing molecules � Cheminformatics resources � Section N - Bioinformatics in the pharmaceutical industry � Bioinformatics and drug discovery � Pharmainformatics resources � Section O � Basic principles of computing in bioinformatics � Running computer software � Computer operating systems � Software downloading and installing � Database management. ISBN - 9781859962725

Pages : 272

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